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Monocarboxylate transporters, or MCTs, constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate, across biological membranes. ==Lactate and the Cori cycle== Lactate has long been considered a byproduct resulting from glucose breakdown through glycolysis in times of anaerobic metabolism. As a means of regenerating oxidized NAD+, lactate dehydrogenase catalyzes the conversion of pyruvate to lactate in the cytosol, oxidizing NADH to NAD+, regenerating the necessary substrate needed to continue glycolysis. Lactate is then transported from the peripheral tissues to the liver. Then, by means of the Cori cycle,it is reformed into pyruvate through the reverse reaction using lactate dehydrogenase. Thus, lactate has traditionally considered a toxic metabolic byproduct that could give rise to fatigue and muscle pain during times of anaerobic respiration. Lactate can be thought of essentially as payment for ‘oxygen debt’ defined by Hill and Lupton as the ‘total amount of oxygen used, after cessation of exercise in recovery there from’. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「monocarboxylate transporter」の詳細全文を読む スポンサード リンク
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